讲座题目：Dietary influences on gut microbiota and the impact on health
主 讲 人：Michael A. Conlon 教授 澳大利亚联邦科工组织健康与生物安全部肠道健康研究组
Michael A. Conlon，男，博士，澳大利亚联邦科工组织健康与生物安全部肠道健康研究组组长（Commonwealth Scientific and Industrial Research Organisation, CSIRO, Health & Biosecurity, Team Leader of Foods and Diet for Gut Health），资深科学家（Senior Research Scientist ），主要从事人类营养学研究。1991-1995 澳大利亚阿德莱德大学生化系（Department of Biochemistry at the University of Adelaide (South Australia)），获理学博士学位；1982-1984 澳大利亚弗林德斯大学，生化系，获理学学士学位。
There is a growing understanding that the microbiota present within the human gut plays an important role in gut health and also aspects of general health. Current molecular methods reveal that there are at least many hundreds of different species in each of our intestines, and the composition of these populations varies between each individual. The acquisition and development of the gut microbiota populations in the early years after birth may be critical to populations in later years and the level of susceptibility to disease. The acquisition and development of the gut microbiota populations in the early years after birth may be critical to populations in later years and the level of susceptibility to disease. There is strong evidence that fermentable dietary fibres can act as prebiotics and promote the growth of beneficial microbes. Of particular interest are fibres such as resistant starches which can stimulate microbial production of the short chain fatty acids (SCFA). In addition to acting as energy sources SCFA have been shown to have multiple functions, including maintenance of gut tissue integrity and stimulation of the immune system. Recent studies suggest dietary fibres and SCFA could play important roles in protecting against allergies in young children and we have been involved in a study to investigate this. Some information on this will be presented in the current talk, along with a description of many of our studies which have examined the roles of foods (especially resistant starches), SCFA or microbes in conditions such as autism spectrum disorder in children, inflammatory bowel disease and colorectal cancer, the latter being more prevalent in later life. Our human study demonstrating that dietary supplementation with resistant starch can protect against dietary red meat-induced colonic DNA damage in people over 50 will be discussed. Topics such probiotics, leaky gut and even faecal microbial transplantation to improve gut health are also likely to be covered.